Big 12 shots. Oh I mean I think that that going to basically like having a good circadian rhythm and, and like bright light exposure in the early morning, like it really does help. I don't know the names changed or not but I thought that was so awesome because she named it after like the sona because the truth comes out, you just start talking like, yeah, start you know, it's intense. Why can't I take my card. So there's one that cross reacts with the Sajko, one which has a very it's very the sequence is very homologous to sars-cov-2 virus. Please do. We were taking the human amyloid beta gene and injecting him in these worms, these nematode worms that only live like 14 or 15 days, and we are making them form amyloid plaques in their muscle. And so it's part of the adaptation process as well, you know, being able to handle the heat stress. They jump in the lake and they go back and they're doing this. And that makes it makes all sorts of problems. It's not. I think we kind of got it dialed in. We did a video on it and like it's I mean, it effects like the insulin secretion, sensitivity, like all that stuff. OK, because I'm sure to do squat like squats are like like every time I do that, yeah. Like I said, I just got a sauna. It's like the number one choking popcorn is like the number one choking. Yeah, it's really it's so horrible. That's a lot. Please give it up for the great and powerful Dr. Rhonda Patrick Girlyman podcast, The Joe Rogan Experience, trained by day Joe Rogan podcast, My Night All Day. Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology. The children, it's real weird with this disease because some children are getting sick, but it's a very small number. Why. She explained that 1,000 IU of vitamin D can raise blood levels around 5-10 ng/mL, depending on a . Most, most of these said three months. Did no. Check out these Podcast Notes from Rhonda's last appearance on Joe's podcast; BPA. He's like, it'll start to heal. So so my doctor might see my dentist is great because he like, you know, any dentist could just be like, no, they're still there. Oh, I think that I think things are going to I mean, I think that these therapeutics can start the monarchal. Do you do you just need more sleep, though? You know, it's important. The Russians like to do that. Even if even if they're wrong, they just love to, like, fixate on confirmation bias. I was just like, you know, he's vomiting. There's a hot bath study where they also elevated wasn't quite as high, but it was like, you know, 40 or so percent higher than baseline levels and it was 104 degrees. Dr. Rhonda Patrick | Joe Rogan Experience - Podcast Notes So why do you take five. Like when I have hard workouts and I get in the sauna afterwards, I feel like my recovery's more rapid. And for me, my problem is my my neck is very thick. But they're also stressed out and they have anxiety in particular, if their bills are piling up and they have no income through. Like his frequent podcast guest Dr. Rhonda Patrick, Rogan is a big fan of vitamin D3. So sleep is so important, but those poor people that it's going to be one of the worst things for your nurses, like doctors, anybody, the first responder, health workers, anybody is working the late shift. So the ginger lemon does. Some of their son is there in Finland. Back in the 60s, there was this antibody dependent enhancement happening. Yes, yes. You could bake, you could grill, you could do literally any kind of cooking you want to do. Right. Yeah. You should have an MRI. I'm not saying that vitamin D is going to prevent you from getting covid-19 or it's a treatment, although I am involved in a clinical study where we're going to be testing a very small open arm study we can talk about. Antibodies from a four year old Belgian llama named Winter Show Promise in blocking coronavirus from infecting cells, according to research from the University of Texas, Austin, the National Institutes of Health and the Ghent I that went into university studying earlier forms of the coronavirus. This does xylitol stuff and I started doing research and then I found all these studies and not only did I find studies that like it, you know, basically kills these bacteria that cause cavities, that mutans pregnant women that chew xylitol gum. Everyone wants randomized control trials like no one wants to believe anything until it's a randomized controlled trial. Joe Rogan - Fasting (Intermittent & Fasting Mimicking Diet) EDIT: If you downvote me and you're not sure why you feel compelled to do so, it's because you want to fuck her and you're white knighting without realising it. I got one pill. And now that business is crushed. You know, there there are some claims out there that are sort of being backed up by very poorly done studies. She's amazing. But that's interesting because your neutrophils, your neutrophils generate hydrogen peroxide. The RDA needs to be like almost three times as high for them. Like I went to Finland a few years ago. You know, like like that's been shown. But, you know, I'm . You know, after doing just so much, of course, the past couple of months, I've been nothing but like reading about the immune system and trying to understand, of course, this new virus, sars-cov-2. So he tracked proteins also do have antiviral activity against at least influenza A.. Right. But what's really interesting is that, you know, the the very receptor that this sars-cov-2 virus binds to to gain entry into the cell, it's called E to that very receptor plays a really important role in preventing lung damage and and basically and preventing acute lung injury, preventing acute respiratory distress syndrome ARDS. And by the time I woke up, I mean, I had bruised myself. I used to do yoga a lot, but, you know, I became a mom and it's like I mean, like I used to work out, like, you know, twice a day, twice a day. Say it again. I should go, something's wrong. You just I couldn't come to an answer. Yeah. It yes. Oh, my son doesn't want to take he doesn't want to sleep ever. So you keep looking down. What doesn't I'm going to move to a place where it's better because I think the way this this state is handling it is fucking terrible. Another study demonstrated the potential of vitamin D as a clinical benefit in population-based trials. And they're not ice baths. Yeah. I mean, the bigger your audience is, the more you get that. So let me tell you my story anyways. It also correlates. I mean, it was just I was thinking, God, if we didn't have this in the house and you couldn't go anywhere, luckily we have one here so I could use the one that's here. So having lower levels may somehow even help protect against. Right? So it seems to me the sweet spot you know, and I've been doing it every single day of the quarantine because I have a song in my house. Man, I think you've got to have the option. That's what it looks like. How about this one. I was like, told you, told you motherfucker. You know, this is like when I was in my early 20s, but I would like dose up on all these like B complex vitamins. Absolutely. Like if you have a herniation of the disc or if you have a bulging disc, it's pushing against your nerve. So vitamin C kind of cycles between being oxidized and reduced is called dehydrator ascorbic acid dehydrates or bait and then ascorbic acid or ascorbic dehydrate. I mean it was like I finally got a jump rope and it came in right when the beaches opened up. But TMJ is, what am I saying, the right thing. But yeah, but zinc seems really important for immune function, like there's been studies where they have like depleted healthy people of their zinc just transiently and like t cell function like is all messed up. Also, as the oldest continuously operating distillery in America, Buffalo Trace Distillery has experienced more than its fair share of adversity floods, fires, wars, recessions and prohibition. I guarantee you it's going to work because I'm so like the whole time I had a gym membership, it's like unpause. And I'll be I'll be honest, I stopped wearing my watch and they're so not measuring my heart rate anymore. The intravenous vitamin C is a completely different game because it literally generates hydrogen peroxide. When the importance of vitamin D is considered in regards to the health of the human body, it becomes essential for good overall health. And I would get on the mechanism. So there's a lot of people in the United States, as you mentioned, you make it from the sun. And I say, crazy asshole. If it's the same disease, I don't think it's warranted. Right. And, you know, I think that that itself it's an interesting field. Like what's happening in vitamin D deficient? No, I like the few studies that I've seen and some people that I like doing insane juicing and they're already, like, messed up, you know, so I'm not concerned at all, like even like the oxalate. Yeah. And I'm like totally relaxed in bed. Twenty percent of all rubs sources in Liner's visit, Tregear grills Dotcom Joe and use the code Rogan at checkout to get free shipping on all orders. Posted by. Rhonda's son is 13 months old, . And there's been large, randomized controlled trials showing that it dramatically reduces mortality with sepsis. But the cold shock, you ask me, cold shock proteins, that that hasn't really been measured in humans. I love like I love Bob. I have I have family members that think it's like infringing their freedom, you know, and like it it does suck. You know, the pharmacokinetic studies that I'm referring to. Archived. It's called the DEA. So, like, what if there's, I don't know, the CMB, you know, percentage there, but what if the coronaviruses are going around there? And so they have like the day I won, it was not Coed Day. It's hard to sleep probably when you're in those. Did it? No, it's the popcorn. And this is why it basically so it it changes your immune system. Right. And and, you know, we need higher quality data. Well, some of them, they have poor people, especially in the beginning when you're seeing these people that were like using makeshift masks and just trying to. That's when I say that's what I get. And I said the only thing that I did, like I could think of is like my obsessive xylitol gum chewing, which I still do. So it causes massive inflammation to have a decrease in it. But now it seems like as times gone on and people getting more frustrated and more desperate and more depressed because they're locked up, it seems like it's ramped up. I used to deliver newspapers, so every morning I was up at five o'clock in the morning and I was also doing comedy. So, I mean, that's the there is there is a push for looking, but not all depressed patients have. Yeah. Yeah, obviously it's in your body, but when you if it's in your nostrils or if it's in your respiratory tract and you're breathing in that heated sauna air, does that have any effect at all on on viruses? I have that outside as well. I mean, he's talked about it before and lots of other researchers have studied this. So this is intravenous dose. Yeah, what what dose do you recommend for intravenous vitamin C? Her break-through work under Dr. Bruce Ames investigated the effects of micronutrient inadequacies on metabolism, inflammation, DNA damage, and aging and whether supplementation can reverse the damage. We were just like we bought freezers I elk burger. Researchers have found an antibody in winter that effectively attached itself in neutralise spike protein in sars-cov-2 one in Cove. Dr. Rhonda Patrick (@foundmyfitness) has a Ph.D. in biomedical science and is an expert on nutritional health. He came up with this machine. When we were talking about song, when people that don't have access to a sauna, how much benefit can they get out of a hot bath? And it's just anyways. And like I remember, I like shared this animal study in an article I wrote years ago before the human study came out. It's been shown to people. Yes, sure. Do you do a C Pap or. Like fuck. It's far infrared and they use it. It's very good stuff. Rhonda Perciavalle Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, Memphis TN, and St. Jude Children's Research Hospital, Memphis, TN. Their levels were 50 percent higher over baseline and which is great. Yeah. TikTok video from Pro D3 (@prod3uk): "@Joe Rogan Experience Dr Rhonda Patrick on the importance of vitamin D supplementation #blowthisup #vitamind #fyp #vitamindeficiency #joeroganpodcast". - 1 capsule/day Vitamin D - Thorne Research D3 - 5,000 IU/day Magnesium - Pure Encapsulations Magnesium Glycinate - 120mg/day Fish Oil - N-PURE-3 - 4 grams/day (currently unavailable, alternative: Carlson Maximum Omega) Rhonda Patrick's Additional Regular Vitamins & Supplements: In the early days of social media before I got a handle on it idea like, fuck, this is stress. I'm glad you brought up hot baths, because that's something that I wanted to cover before we got off track. That's similar to what we have. I'll show how it works before. And so like I mean, you're breathing like it's like burning you. Podcast Notes is a Signal From the Noise LLC Production, All Right Reserved, Berkshire Hathaway Annual Shareholders Meeting, Christopher Lockhead's Follow Your Different, Everyday Espionage Podcast with Andrew Bustamante, Feel Better, Live More With Dr. Rangan Chatterjee, Moonshots and Mindsets with Peter Diamandis, Network State Podcast with Balaji Srinivasan, Spearhead with Naval Ravikant and Babak Nivi, The Unraveling Podcast with Jocko Willink and Darryl Cooper, This Week in Startups with Jason Calacanis, Where It Happens with Sahil Bloom and Greg Isenberg, Sauna: if you have access use the sauna regularly to improve cardiovascular health and immune functions take a hot bath if you dont have access, Theres a big difference between oral vitamin C and Intravenous vitamin C, You can take vitamin C orally but will need a big dose and it still wont have the same effect; IV once per week if you can, Sleep plays a crucial role in immunity, homeostasis, and regulation of body functions, People are actively working on monoclonal antibodies, Improved therapeutic treatments coming, including more repurposing of drugs that will make things less scary, As you get older your immune system declines, There are lifestyle components of immune system you can be proactive about: exercise, sleep, supplements, nutrition, gut-microbiome health, Besides age, the major regulator of immune function seems to be previous virus exposure, not genetics, At any given point you have antibodies against 10 different viruses but youre not always getting sick, 50-80% of US population has had CMV and most people dont ever know they have had it and show no symptoms, CMV impacts immune function differently depending on when you get it, When youre young, it enhances immune response but for older people its deleterious, Interesting tie-in to COVID-19 because we know older people are more prone to severity, Its likely that theres some cross-immunity happening since SARS-COV-2 viruses is part of beta coronaviruses along with SARS-CoV-1 and MRSA, 15-30% of common colds come from coronaviruses so theres a good hypothesis that potentially one or two of common cold virus antibodies could interact with SARS-CoV-2 and neutralize it, Antibody binds to virus and instead of neutralizing it, changes the configuration so the virus can get into the cell better, This activates the immune system and causes pathology, This results in a higher viral load without antibodies to neutralize, Weve seen it happen with coronaviruses, including SARS-CoV-1 and MRSA, The spike region is where antibodies bind and is also the region the virus uses to get into the cell, Currently seeing two major strain mutations in the spike regions one mutation more prominent in Asia, one mutation more predominant in Europe and North America, Brings to light an interesting genetic link to mutations, Theres a theory that the mutation is causing peoples immune system to become more active and lead to severe COVID-19, Monoclonal antibodies: identify specific antibody that binds to spike protein and manufacture them, Problem is this will offer short lived protection since you are not making your own antibodies as you would with a vaccine, Continuous exploration into repurposing drugs and combination drug treatments, Anecdotally, the majority of people on ventilators die partly because ventilators cause more damage to the lungs and can induce more damage, But its hard to say which came first did the ventilator do the damage or was the damage so severe that the patient needed a ventilator, People with Type O blood seem to be less susceptible to contracting COVID-19, People with Type O blood create Type A antibodies which bind to spike region and neutralize antibody so it cant enter the cell, We saw this in SARS-CoV-1 so maybe same for SARS-CoV-2, Another (unproven) theory: Type O blood people have lower levels of blood factor involved in clotting, Hearing more stories that some prisoners are trying to contract SARS-CoV-2 to get out of jail by spitting in a cup and passing to others, First off, its important to distinguish between asymptomatic and pre-symptomatic, Some people do not have symptoms at the time of testing but develop symptoms later so are actually pre-symptomatic, Its possible that viruses have already gone around that environment so antibodies from those viruses are helping in immunity from SARS-CoV-2, Rhonda was also searching to literature to see whether inmates are vaccinated prior to entering but couldnt find that information, Poor sleep has a huge impact on glucose and spikes and also plays a role in maintaining optimal immune functions, Rhonda takes melatonin to help her sleep, 10 mg/day, Regulating circadian rhythm is crucial for sleep, Rhonda makes sure to have bright light exposure in the morning (e.g., opening curtains, walking outside), and changes the lighting in the house in the evening to red lights, 70% of US population has insufficient Vitamin D levels; 28% are deficient, Body can generate naturally when exposed to sun daily, Obese people in US are also more likely to be vitamin D deficient, Genetic polymorphisms: people that have variations in genes that cause them to have less vitamin D, These people are more likely to die from respiratory infection, African Americans in the US are 28x more deficient in vitamin D than Caucasians, A recent study that looked at COVID-19 patients observed an inverse relationship between vitamin D levels and COVID-19 symptoms: the lower the vitamin D levels, the higher the severity of COVID-19, In Indonesia almost all patients that died from COVID-19 were vitamin D deficient, Melanin blocks ability to produce Vitamin D, In the US and Europe, African Americans and black people are more likely to die from COVID-19, Even when adjusting for SES and lifestyle factors, this was still true so something else must be happening, Tolerable upper intake is 4000 IUs per day but its best to get vitamin D blood test to measure levels, There are clinical studies exploring the role of vitamin D but not many in the US, Rhonda wants to see nurses and first responders take vitamin D to see the role in prevention but those studies are not being done, Joe uses the sauna 7 days/week, 180-degrees for 25 min, Rhonda uses the sauna 5 days/week, 180-degrees for 25 min, Heart rate variability improves, blood pressure goes down, cardiovascular health improves, all-cause mortality decreases, Sauna use also improves immune system and makes you more resilient against infection, Brain-derived neurotropic factors (BDNF) increases with exercise and heat stress (sauna), The positive benefits of physical activity on the cardiovascular system were enhanced when sauna was added, Sauna use increases heat shock proteins which prevent muscle atrophy, neurodegenerative genes, and have anti-depressant effects, People who sat in 160-degree sauna for 30 minutes had a 60% increase in heat shock protein compared to baseline, Large Harvard study being done to assess whether hot yoga increases heat shock protein, Heat shock protein have antiviral activity against influenza A, Regular sauna is heating ambient air which in turn raises core body temperature, Infrared saunas are directly heating body without heating the ambient air for example, in a heating tent or blanket, We know more about the effects of dry sauna, For people who dont have access to sauna, a hot bath is a good modality for heat shock protein, Studies being done to assess whether sauna can have anti-depressant effect on depressed patients, Saunas could also provide an avenue for giving sedentary and disabled people the benefits of physical activity without exercising, Ice baths and cold showers can be comparable to cryotherapy but you have to stay in the cold water longer, Cold shock protein hasnt really been measured in humans, instead whats measured is norepinephrine which has been shown to increase, Cold shock protein and hot shock protein have been shown to improve mood as well, The pharmacokinetics of vitamin C are very different in oral vs IV consumption, Oral vitamin C is good for immune function, etc.

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